Explore how naltrexone treatment for opioid addiction works, its benefits, side effects, and effectiveness compared to other medications like Suboxone. Discover if it’s right for you.
What Is Naltrexone?
Naltrexone is an FDA-approved medication used in medication-assisted treatment (MAT) for opioid and alcohol addiction. Unlike opioids, it is non-addictive and works by blocking opioid receptors in the brain, preventing euphoric effects and reducing cravings.
How Does Naltrexone Treatment Work?
- Mechanism: Binds to opioid receptors, blocking drugs like heroin, fentanyl, or oxycodone from producing a high.
- Forms:
- Oral Naltrexone: Taken daily (50mg tablet).
- Vivitrol (Injectable Naltrexone): Administered monthly by a healthcare provider, improving adherence.
- Detox First: Patients must complete detox (7–10 days opioid-free) to avoid severe withdrawal.
Benefits of Naltrexone for Opioid Addiction
- Non-Addictive: No risk of misuse or dependence.
- Reduces Cravings: Helps stabilize brain chemistry.
- Long-Acting Option: Vivitrol’s monthly shot minimizes daily pill burden.
- Complements Therapy: Works best with counseling or behavioral therapy.
Naltrexone vs. Suboxone and Methadone
| Feature | Naltrexone/Vivitrol | Suboxone (Buprenorphine) | Methadone |
| Addiction Risk | None | Low | High |
| Administration | Daily pill/monthly shot | Daily dissolvable film | Daily clinic visit |
| Withdrawal Relief | No | Yes | Yes |
| Cost | $$ (Vivitrol) | $$ | $ |
Key Takeaway: Naltrexone suits motivated patients post-detox, while Suboxone/methadone are better for managing withdrawal.
Effectiveness of Naltrexone
- Relapse Reduction: Studies show Vivitrol cuts relapse risk by 50% in 6 months when combined with therapy.
- Adherence Matters: Injectable Vivitrol has higher success rates due to consistent dosing.
- Limitations: Requires full detox first; not effective for active users.
Side Effects and Risks
- Common: Nausea, headache, fatigue, insomnia.
- Rare: Liver toxicity (monitored via blood tests), injection-site reactions (Vivitrol).
- Contraindications: Avoid if using opioids or pregnant (limited data).
How to Start Naltrexone Treatment
- Detoxification: Complete 7–10 days opioid-free.
- Consult a Provider: Find a certified MAT clinic or addiction specialist.
- Choose Form: Opt for daily pills or Vivitrol injections.
- Combine with Support: Engage in counseling (e.g., CBT) for best outcomes.
Pro Tip: Use SAMHSA’s treatment locator to find naltrexone providers near you.
FAQs About Naltrexone for Opioid Addiction
Q: How long does naltrexone stay in your system?
A: Oral naltrexone lasts 24–48 hours; Vivitrol blocks opioids for ~30 days.
Q: Can I overdose on naltrexone?
A: No, but using high opioid doses to override it may lead to fatal overdose.
Q: Is Vivitrol covered by insurance?
A: Most plans cover it, and manufacturer discounts are available.
Q: Does naltrexone help with alcohol addiction?
A: Yes—it’s also FDA-approved for alcohol use disorder.
Conclusion
Naltrexone offers a safe, non-addictive path to opioid addiction recovery, especially for committed patients post-detox. While Vivitrol’s monthly injections improve adherence, success hinges on combining medication with behavioral support. Consult a healthcare provider to determine if naltrexone fits your recovery goals.
Call to Action: Ready to explore naltrexone? Use our clinic locator or call Sal Rediscovery Center
to start your journey today.
